MersV1, Main, Exploration, bibRecord, 004213

Brief overview of control of genetic expression by antisense oligonucleotides and in vivo applications

Identifieur interne : 004213 ( Main/Exploration ); précédent : 004212; suivant : 004214

Brief overview of control of genetic expression by antisense oligonucleotides and in vivo applications

Auteurs : Gerald Zon [États-Unis]

Source :

Molecular Neurobiology [ 0893-7648 ] ; 1995-04-01.

RBID : ISTEX:65D6AC5292069BFAB889E42B63B5AD075E794D78

English descriptors

KwdEn :
- Genetic expression, animal models, antisense, in vitro activity, neurobiology, oligonucleotides, phosphorothioate analogs.
Teeft :
- Acad, Additional reports, Analog, Animal models, Antisense, Antisense agent, Antisense agents, Antisense approach, Antisense oligonucleotide, Antisense oligonucleotide analogs, Antisense oligonucleotides, Antisense phoshorothioate studies, Antisense phosphorothioate, Antisense phosphorothioates, Boca raton, Brief overview, Carotid artery, Cell culture, Cell type, Chronic meylogenous leukemia, Coding strand, Considerable attention, Daily dose, Early studies, Gene expression, Genetic expression, Infusion, Interception process, Large number, Local delivery, Local intraluminal, Marrow purge, Molecular neurobiology, Myelogenous leukemia, Natl, Neurobiology, Nude mouse, Oligonucleotide, Oligonucleotides, Personal communication, Phosphorothioate, Phosphorothioate analog, Phosphorothioate analogs, Phosphorothioate antisense, Proc, Recent reports, Receptor, Subcutaneous injections, Synthetic oligonucleotides, Systemic infusion, Viral diseases, Whitesell.

Abstract

Abstract: Over the past several years, the use of synthetic oligonucleotides and functional analogs thereof as a possibly general means of controlling genetic expression has received widespread attention. Following a brief overview of some of the basic principles and strategies for this approach, attention is focused here on summarizing some recent reports of in vitro and, in particular, in vivo investigations in various animal models using phosphorothioate analogs of 2′-deoxyoligo-nucleotides. In view of these findings, which include studies related to neurobiology, this field should find significant utility in applications of the antisense method for controlling genetic expression.

Url:

https://api.istex.fr/ark:/67375/1BB-GR65BXVQ-4/fulltext.pdf

DOI: 10.1007/BF02740677

Affiliations:

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Le document en format XML

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<term>Antisense agent</term>
<term>Antisense agents</term>
<term>Antisense approach</term>
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<term>Daily dose</term>
<term>Early studies</term>
<term>Gene expression</term>
<term>Genetic expression</term>
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<term>Interception process</term>
<term>Large number</term>
<term>Local delivery</term>
<term>Local intraluminal</term>
<term>Marrow purge</term>
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<term>Myelogenous leukemia</term>
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<term>Neurobiology</term>
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<term>Phosphorothioate analogs</term>
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<term>Recent reports</term>
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<term>Subcutaneous injections</term>
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<front><div type="abstract" xml:lang="en">Abstract: Over the past several years, the use of synthetic oligonucleotides and functional analogs thereof as a possibly general means of controlling genetic expression has received widespread attention. Following a brief overview of some of the basic principles and strategies for this approach, attention is focused here on summarizing some recent reports of in vitro and, in particular, in vivo investigations in various animal models using phosphorothioate analogs of 2′-deoxyoligo-nucleotides. In view of these findings, which include studies related to neurobiology, this field should find significant utility in applications of the antisense method for controlling genetic expression.</div>
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Brief overview of control of genetic expression by antisense oligonucleotides and in vivo applications

Brief overview of control of genetic expression by antisense oligonucleotides and in vivo applications

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri